![]() porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system).endometriosis or uterine fibroid tumors.liver problems, or jaundice caused by pregnancy or taking hormones.You are even more at risk if you have high blood pressure, diabetes, high cholesterol, if you are overweight, or if you smoke.Įstradiol should not be used to prevent heart disease, stroke, or dementia, because this medicine may actually increase your risk of developing these conditions. Using this medicine can increase your risk of blood clots, stroke, or heart attack. Tell your doctor right away if you become pregnant during treatment. a history of hormone-related cancer, or cancer of the breast, uterus/cervix, or vagina.ĭo not use estradiol if you are pregnant.an increased risk of having blood clots due to a heart problem or a hereditary blood disorder or.a history of heart attack, stroke, or blood clot. ![]() unusual vaginal bleeding that has not been checked by a doctor.You should not use this medicine if you are allergic to estradiol, or if you have:
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